Y.E.S. Fitness "Longevity" Podcast
Highlights of the Episode
00:00 - What are we talking about today?
01:33 - What percentage of our longevity depends on our genes?
02:10 - What is the second thing we’re talking about?
02:38 - What is the project Chris is releasing in the fall?
03:19 - What is the first stage in aging?
03:30 - What is genomic instability?
07:19 - What is telomere attrition?
09:05 - What is epigenetic alterations?
11:36 – What is proteostasis?
12:13 - What is homeostasis?
13:40 – What is autophagy?
14:08 - What are antagonistic hallmarks?
14:23 - What is deregulation of nutrient sensing?
16:09 - What is mitochondrial dysfunction?
17:38 - What is cellular senescence?
19:03 – What are the integrative hallmarks?
19:18 - What is stem cell exhaustion?
21:00 – What is inflammaging?
21:14 - Who is David Sinclair?
23:30 - What is the Information Theory of Aging?
24:23 - What is the SIR2 gene?
24:34 - What are sirtuins?
26:25 - What is NAD?
29:58 - What is mTOR?
33:04 - Why are temperature changes so important?
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